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PREGNANCY-ASSOCIATED PLASMA PROTEIN-A
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DeCS
Descriptor
English
:
Pregnancy-Associated Plasma Protein-A
Descriptor
Spanish
:
Proteína Plasmática A Asociada al Embarazo
Descriptor
Portuguese
:
Proteína Plasmática A Associada à Gravidez
Synonyms
English
:
PAPP-A
Tree Number:
D08.811.277.656.300.480.632
D08.811.277.656.675.374.632
D12.776.780.700
Definition
English
:
A product of the
PLACENTA
, and
DECIDUA
, secreted into the maternal circulation during
PREGNANCY
. It has been identified as an IGF binding protein (IGFBP)-4 protease that proteolyzes IGFBP-4 and thus increases IGF bioavailability. It is found also in human
FIBROBLASTS
, ovarian
FOLLICULAR FLUID
, and
GRANULOSA CELLS
. The enzyme is a heterotetramer of about 500-kDa.
History Note
English
:
2004 (1996)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
11686
Unique Identifier:
D011266
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
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